Immune Oncology

Clinical Neuroscience

JANUARY 30, 2024

Progressive multifocal leukoencephalopathy with a benign prognosis in an immunocompetent patient – A case report

ZEYNEP ÖZDEMIR, SERAP Ruken TEKER, BURCU YÜKSEL, AYSUN SOYSA

John Cunningham virus (JCV) is most commonly acquired in childhood and is often asymptomatic throughout life. However, in the case of primary or secondary immunosuppression, it is known to cause progressive multifocal leukoencephalopathy (PML) in the central nervous system. Hereby, we describe a rare case of PML in a patient without known factors of immunosuppression or use of immunomodulation.

ENG 2024;77(1-2)

Clinical Neuroscience

JANUARY 30, 2024

[Guillain-Barré syndrome caused by intravesical instillation of Bacillus Calmette-Guérin]

AKAN Serkan , ATMACA Colak Melek

[ Guillain-Barré syndrome is an acute inflammatory demyelinating polyneuropathy. In the vast majority of patients, 1-4 weeks before the onset of GBS-related symptoms, an event such as upper respiratory tract or gastrointestinal tract infection, surgical intervention or vaccination is present. To the best of our knowledge, this is the first case of GBS that occurred after intravesical Bacillus Calmette-Guérin therapy in the absence of tuberculosis or any other infection in the English literature.]

HUN 2024;77(1-2)

Lege Artis Medicinae

FEBRUARY 20, 2024

[Recent results of lifestyle  and drug-induced body-weight reduction ]

BAJNOK László

[Among the specific weight loss diets, there is no convincing fundamental difference in their short-term effects. There is no magic bullet since weight regain is common with all methods in the long term (the greater the reduction the greater the regain). Thus for the majority of patients in need none of them has any significant outcome (–10% per 2 years). Only the safety of some dietary methods has been clarified so far. Although the Mediterranean diet is generally accepted (in a broader context, the Smart Plate developed for domestic conditions by the National Association of Hungarian Dietitians too), however intermittent fasting and e.g. the time-restricted eating may also have some advantages. It would be reasonable to attribute more importance to the patient’s preference during the (repeated) dietetic consultations (the question is who could mediate it authentically?) Nutritional therapy requires essentially (or should require) medical treatment of excess weight, which would also support growing-up of obesitology. In me­tabolic medicine, entero-hormones, primarily glucagon-like peptide-1 receptor agonists (GLP-1 RA), opened a new chapter in the history of medicine. Newer, more ef­fective forms of this drug family make at least 10% weight loss attainable to most of those in need, and as long as their use continues its cardiovascular benefits have also been proven.]

HUN 2024;34(1-2)

Hypertension and nephrology

DECEMBER 18, 2023

[Cardio-renal-metabolic approach in medicine – thoughts, considerable information based on the new recommendations regarding SGLT2 inhibitors and GLP1 receptor agonists]

WAGNER László

[Common complications of type 2 diabetes are chronic kidney failure and chronic heart failure. However, chronic renal failure and chronic heart failure can contribute to the development and deterioration of each other, and can be present earlier and more severely in the case of diabetes. Furthermore, type 2 diabetes might also occur more frequently in case of chronic kidney- and heart failure. All of these are often accompanied by atherosclerotic cardiovascular disease and hypertension.]

HUN 2023;27(06)

Hypertension and nephrology

DECEMBER 18, 2023

[Cardio-renal-metabolic approach in medicine – thoughts, considerable information based on the new recommendations regarding SGLT2 inhibitors and GLP1 receptor agonists 2. ]

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HUN 2023;27(06)

Clinical Neuroscience

NOVEMBER 30, 2023

Changes in the hippocampal volume in chronic migraine, episodic migraine, and medication overuse headache patients

MAHMUT Nedim AYBAKAN, GIZEM GÜRSOY, NEVIN PAZARCI

Hippocampi are the structures located in the medial depths of both temporal lobes, mainly responsible for memory, navigation and regulation of emotions, and activated during the processing of pain and the modification of nociceptive stimuli. Chronic pain is thought to have stress-like detrimental modulatory effects on the hippocampal neurogenesis, and adults with chronic pain have been showed to have lower hippocampal volumes. a

ENG 2023;76(11-12)